Welcome to the Pedersen Lab Homepage. Our lab was established in 1967, as part of the Department of Biological Chemistry (initially named Physiological Chemistry until 1984) at The Johns Hopkins University School of Medicine located in Baltimore, Maryland.
 
Our laboratory is interested in cell energetics and the relationship of cell energetics to molecular medicine and disease. Both mitochondrial and glycolytic processes are being studied at the tissue, cell, and molecular level. Also, the relationship of these processes to the diseases cancer and heart disease, the two major causes of death in the U.S. are being studied with the objective of discovering and developing new therapies.
 
Specific projects in the laboratory that are currently under investigation include: 1.) The structure, mechanism, and regulation of the mitochondrial ATP synthase/ATPase complex, 2.) The molecular basis of cancer’s most common phenotype, i.e., an elevated glucose metabolism, and 3.) The regulation of heart function under normal and ischemic conditions as it relates to the mitochondrial ATP synthase/ATPase complex.

Our team consists of chemists, biologists, and clinicians that work together in a highly collaborative environment. The laboratory is currently supported by grants from the National Institutes of Health, etc.
3-Bromopyruvate: a
novel antifungal agent...
  [2013 Biochem Biophys... ]
 
Butyrate activates
the monocarboxylate...
  [2012 J Bioenerg Biom... ]
 
A translational
study "case report" on...
  [2012 J Bioenerg Biom... ]
 
3-bromopyruvate
(3BP) a fast acting,...
  [2012 J Bioenerg Biom... ]
 
Transport and
cytotoxicity of the...
  [2012 J Bioenerg Biom... ]